Endocrine Abstracts

Background: Diagnosis and monitoring of thyroid diseases rely on thyroid function tests. Testing for Thyroid Stimulating Hormone (TSH) and free thyroxin (FT4) are frontline assays for the diagnosis of hyper- and hypothyroidism. Measurement of TSH receptor autoantibodies (TRAB) is pivotal for the diagnosis of Graves’ disease. Our study objective was to determine the performances of ABEI-based automated immunoassays for measurement of TSH, FT4 and TRAb.<p class="abstext...

Background: Quantification of 1,25-dihydroxyvitamin D (1,25(OH)2D) remains challenging because of low circulating concentrations and potent cross-reactivities with steroid-like structures. The most frequent assays for 1,25(OH)2D testing are still based on RIA format with preliminary extraction. The analytical performances and the turnaround time of analysis (TAT) for these assays are limited. Several novel assays for 1,25(OH)2D testing are emer...

Introduction: Measurement of aldosterone, the major mineralocorticoid secreted by adrenal cortex, is important for the screening of primary aldosteronism and for the clinical assessment of hypertensive patients. RIA remain widely used for the measurement of aldosterone but some automated immunoassays are emerging. The aim of our study was to evaluate the performances of a new automated aldosterone immunoassay.Methods: Method imprecision of the Liaison&#1...

Introduction: Circulating insulin levels are widely used to provide diagnostic information for diabetes mellitus and hypoglycaemic syndromes. C-peptide concentration provides an accurate assessment of residual B-cell function and reliable information about insulin secretion in patients with diabetes. The aim of this study was to evaluate the performances and reliability of the Liaison® fully automated system for measurement of insulin and C-peptide concentratio...

Background: Vitamin D is an important contributor to musculoskeletal health and its potential involvement has recently been underlined in several non-skeletal diseases. Measurement of circulating levels of 25-hydroxyvitamin D (25OHD) represents the most reliable assessment of vitamin D status. Several assays are available but are not commutable because of a lack of of standardization. The aim of our study was to evaluate the performance of a new ELISA for measurement of 25OHD ...

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...

Patients with hypoparathyroidism are at risk of short-term and long-term complications and comorbidities, such as renal, cardiovascular, metabolic or cognitive manifestations. The purpose of this study was to determine the burden of illness (BOI) in patients with not adequately controlled chronic hypoparathyroidism receiving conventional therapy (oral calcium supplements and active vitamin D) in Belgium and the Netherlands. Data werecollected from a cross-sectional, 2-part onl...

Objectives: Surgery of pheochromocytomas (PC) still carries a high risk of hemodynamic complications during the perioperative period. We aimed to evaluate the influence of their secretory phenotype and preoperative alpha-blocker treatment on surgical outcome.Design: A retrospective monocentric study at a tertiary medical center.Patients: 80 consecutive patients operated for an adrenal PC between 1988 and 2018.<p class="abstext"...

Background: Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Latest BV data on thyroid parameters in adults included in the EFLM Biological Variation Database have been published in 2008.Objectives: We aimed at determining the BV of four thyroid function test (thyroid-stimulating hormone (TSH), free thyrox...